Advanced stratification analyses in molecular association meta-analysis: methodology and application
نویسندگان
چکیده
منابع مشابه
Controlling for confounding factors and revealing their interactions in genetic association meta-analyses: a computing method and application for stratification analyses
Subgroup and stratification analyses have been widely applied in genetic association studies to compare the effects of different factors or control for the effects of the confounding variables associated with a disease. However, studies have not systematically provided application standards and computing methods for stratification analyses. Based on the Mantel-Haenszel and Inverse-Variant appro...
متن کاملMeta- and Pooled Analyses The Association Between Atopy and Childhood/Adolescent Leukemia: A Meta-Analysis
Atopic disease is hypothesized to be protective against several malignancies, including childhood/adolescent leukemia. To summarize the available epidemiologic evidence, the authors performed a meta-analysis of associations between atopy/allergies, asthma, eczema, hay fever, and hives and childhood/adolescent leukemia, acute lymphoblastic leukemia (ALL), and acute myeloid leukemia (AML). They s...
متن کاملMethodology and reporting of systematic reviews and meta-analyses.
BACKGROUND Relatively little is known of the use of systematic review and synthesis methods of non-randomised psychiatric epidemiological studies, which play a vital role in aetiological research, planning and policy-making. AIMS To evaluate reviews of psychiatric epidemiological studies of functional mental disorders that employed synthesis methods such as systematic review or meta-analysis,...
متن کاملAssociation Analysis under Population Stratification: A Two-Stage Procedure Utilizing Population- and Family-Based Analyses.
OBJECTIVE The association analysis based on a population-based case-control study is convenient and powerful, but may be biased under population stratification (PS), namely the study population consists of strata heterogeneous in disease rates and allele frequencies. On the other hand, a family-based (e.g. case-parents) study is robust against the PS bias, but may be less convenient to implemen...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMC Medical Research Methodology
سال: 2020
ISSN: 1471-2288
DOI: 10.1186/s12874-020-01020-z